Chemiluminescence immunoassay (CLIA) is a widely used detection method which combines the highly-sensitive chemiluminescence assay with highly-specific immune response and affinity of antibodies. Currently, CLIA is the latest to be developed and the most advanced immunoassay technology. Since its initial assay development, CLIA became a mature and advanced ultra-sensitive detection technology enabling the detection of trace amounts of analytes. The advantages of CLIA mainly include high sensitivity and specificity , high stability of reagents, rapid detection and simple operation.